Description

(R)-3-(4-Fluorophenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and psychiatric drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking a reliable source of a key enantiomerically pure scaffold.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates targeting neurological receptors.
• Asymmetric Synthesis: Used as a building block for creating complex, enantiomerically pure molecules in medicinal chemistry.
• Chemical Research: Serves as a reference standard and starting material in academic and industrial research exploring structure-activity relationships (SAR).
• Ligand and Catalyst Development: Potential use in the development of chiral ligands for catalytic asymmetric transformations.
• Preclinical Development: Supplied in development quantities for preclinical studies and early-stage process chemistry.

Basic Information

Product Name	(R)-3-(4-Fluorophenyl)Pyrrolidine Hydrochloride
CAS No.	2165331-30-4
Molecular Formula	C10H13FN•HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	(R)-3-(4-Fluorophenyl)pyrrolidine HCl; (R)-3-(p-Fluorophenyl)pyrrolidine hydrochloride; (3R)-3-(4-Fluorophenyl)pyrrolidin-1-ium chloride; (R)-3-(4-Fluorophenyl)-1-azabicyclo[3.2.0]heptane hydrochloride (incorrect but common misnomer); (R)-4-Fluoro-β-proline ethyl ester hydrochloride (related derivative); (R)-FPP-HCl; (R)-3-(4-FP)Pyrrolidine•HCl
EINECS	Contact for details

Quality Control

Our (R)-3-(4-Fluorophenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and impurity profiles are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.