Description

[S(R)]-n-[(S)-[4-(1,1-Dimethylethyl)Phenyl][5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-2-Methyl-2-Propanesulfinamide CAS NO 2160535-59-9 is a sophisticated chiral sulfinamide ligand, distinguished by its integration of a xanthene-based phosphine moiety. This compound is critically important as a highly effective catalyst or ligand in asymmetric synthesis, enabling the production of enantiomerically pure intermediates essential for advanced pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: As a chiral ligand for transition metal catalysts (e.g., Rh, Ru, Ir) in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: For the construction of chiral centers in active pharmaceutical ingredients (APIs), including those for cardiovascular, oncological, and neurological therapies.
• Asymmetric C-C Bond Formation: Facilitating key reactions such as cross-coupling, allylic alkylation, and conjugate additions with high enantiomeric excess (ee).
• Agrochemical Research: In the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: Serving as a valuable tool for methodological development in organic synthesis and catalysis studies.
• Fine Chemical Production: For the manufacture of specialty chemicals, flavors, and fragrances requiring specific chirality.

Basic Information

Product Name	[S(R)]-n-[(S)-[4-(1,1-Dimethylethyl)Phenyl][5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2160535-59-9
Molecular Formula	C48H48NO2PS
Molecular Weight	733.93 g/mol
Synonyms	(SR)-N-[(S)-[4-(tert-Butyl)phenyl][5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]methyl]-2-methylpropane-2-sulfinamide; tert-Butanesulfinamide Xantphos Derivative; Chiral Xantphos-Sulfinamide Ligand; (S)-tert-Butanesulfinamide-based Xantphos Ligand; Asymmetric Sulfinamide-Phosphine Hybrid Ligand; CAS 2160535-59-9
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical purity and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications. We support development under cGMP and ISO 9001 guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.