Description

[S(R)]-n-[(R)-[4-(1,1-Dimethylethyl)Phenyl][5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide ligand featuring a xantphos-derived phosphine group, designed for high-performance asymmetric catalysis. This compound is critical for enabling highly enantioselective transformations in pharmaceutical and fine chemical synthesis, where precise stereochemical control is paramount. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel synthetic routes with superior selectivity and yield.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, such as hydrogenation, cross-coupling, and hydroformylation.
• Key component in the synthesis of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Use in process chemistry for the scale-up of enantiomerically pure intermediates.
• Catalyst development for academic and industrial research in organic synthesis.
• Enabling technology for the production of agrochemicals and flavors & fragrances with defined chirality.
• Potential application in materials science for creating chiral polymers or frameworks.

Basic Information

Product Name	[S(R)]-n-[(R)-[4-(1,1-Dimethylethyl)Phenyl][5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2160535-58-8
Molecular Formula	C48H48NO2PS
Molecular Weight	733.93 g/mol
Synonyms	(SR)-N-[(R)-[4-(tert-Butyl)phenyl][5-(Diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]methyl]-2-methylpropane-2-sulfinamide; Chiral Xantphos Sulfinamide Ligand; tert-Butanesulfinamide Xantphos Derivative; (R)-DTBM-SEGPHOS Sulfinamide Analog; Asymmetric Sulfinamide-Phosphine Hybrid Ligand; CAS 2160535-58-8
EINECS	Contact for details

Quality Control

Every batch of this advanced chiral ligand is produced and tested under strict quality management to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation. Our quality systems support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.