Description

[S(R)]-n-[(S)-[5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl](4-Methoxyphenyl)Methyl]-2-Methyl-2-Propanesulfinamide CAS NO 2160535-57-7 is a sophisticated chiral sulfinamide ligand, featuring a xanthene-based phosphine backbone, designed for high-performance asymmetric catalysis. This compound matters because it enables precise stereochemical control in critical bond-forming reactions, offering researchers and process chemists a powerful tool to synthesize enantiomerically pure intermediates and active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on developing novel synthetic methodologies for complex organic molecules.

Application

• As a key chiral ligand in transition metal-catalyzed asymmetric reactions, such as hydrogenation, cross-coupling, and hydroformylation.
• For the stereoselective synthesis of chiral amines, alcohols, and other pharmaceutically relevant building blocks.
• In the research and development of new catalytic processes for the production of enantiomerically pure compounds.
• As a critical component in catalyst screening kits for high-throughput experimentation (HTE) in drug discovery.
• For the preparation of custom catalyst systems tailored to specific industrial-scale asymmetric transformations.
• In academic studies investigating structure-activity relationships (SAR) of phosphine-sulfinamide ligands in catalysis.

Basic Information

Product Name	[S(R)]-n-[(S)-[5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl](4-Methoxyphenyl)Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2160535-57-7
Molecular Formula	C42H40NO3PS
Molecular Weight	669.82 g/mol
Synonyms	(SR)-N-[(S)-[5-(Diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl](4-methoxyphenyl)methyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-[5-(Diphenylphosphino)-9,9-dimethylxanthen-4-yl](4-methoxyphenyl)methyl]-2-methylpropane-2-sulfinamide; XantPhos-Sulfinamide Ligand; Chiral Xantphos Sulfinamide Derivative; (SR)-N-[(S)-[5-(Diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl](4-methoxyphenyl)methyl]-2-methyl-2-propanesulfinamide; Asymmetric Sulfinamide-Phosphine Hybrid Ligand
EINECS	Contact for details

Quality Control

Our high-value chiral ligands are produced and handled under strict quality-controlled environments to ensure batch-to-batch consistency and optimal catalytic performance. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity, NMR for structural confirmation, and elemental analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; the container should be kept under an inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.