Description

Olaparib D5 is a deuterated isotopologue of the potent and selective PARP inhibitor Olaparib, where five hydrogen atoms are replaced with deuterium. This compound is a critical reference standard and internal standard used in quantitative bioanalytical methods, particularly LC-MS/MS, to ensure accurate pharmacokinetic and metabolic studies. It is essential for pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories focused on oncology drug development and clinical trials.

Application

• Bioanalytical Reference Standard: Serves as a primary standard for the quantification of Olaparib in biological matrices (plasma, serum, tissue) using mass spectrometry.
• Metabolite Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to trace and identify metabolites, leveraging the kinetic isotope effect.
• Clinical Trial Support: Critical for ensuring data integrity and regulatory compliance in bioanalysis during clinical trials for PARP inhibitor therapies.
• Method Development & Validation: Employed as an internal standard to improve the accuracy, precision, and reproducibility of analytical methods for Olaparib.
• Pharmaceutical Quality Control: Supports impurity profiling and stability testing of Olaparib drug substance and product.
• Research Tool: Utilized in academic and industrial research to investigate the detailed mechanism of action and resistance pathways of PARP inhibition.

Basic Information

Product Name	Olaparib D5
CAS No.	2143107-56-4
Molecular Formula	C24H18D5FN4O3
Molecular Weight	435.48 g/mol (deuterated form)
Synonyms	AZD-2281 D5; KU-0059436 D5; Lynparza D5; 4-[[3-[4-(Cyclopropylcarbonyl)piperazin-1-yl]carbonyl]-4-fluorophenyl]methyl(2H)phthalazin-1-one D5; (3S)-3-[4-(Cyclopropylcarbonyl)piperazine-1-carbonyl]-4-fluorobenzyl (2H)-phthalazin-1-one D5; Olaparib (phenyl-d5); PARP Inhibitor Olaparib D5
EINECS	Contact for details

Quality Control

Our Olaparib D5 is manufactured under strict quality systems to ensure the highest standards for research and analytical use. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, chemical purity, isotopic purity, and chromatographic data. We adhere to relevant industry guidelines to support GLP and GMP-compliant research. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.