Description

Tco-Peg2-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a thermolabile TCO (trans-cyclooctene) group and a primary amine terminus. This compound is engineered to facilitate efficient, bioorthogonal conjugation strategies, particularly in the development of advanced bioconjugates and drug delivery systems. It is a critical reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors who require precise and stable linkages for payload attachment.

Application

• Bioorthogonal Conjugation Chemistry: Utilized in inverse electron-demand Diels-Alder (IEDDA) reactions with tetrazines for rapid, catalyst-free, and high-yield bioconjugation.
• Antibody-Drug Conjugate (ADC) Development: Serves as a cleavable linker for attaching cytotoxic payloads to monoclonal antibodies, leveraging the TCO-tetrazine click reaction for site-specific conjugation.
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Acts as a flexible spacer to connect E3 ligase ligands to target protein binders, aiding in the construction of novel bifunctional molecules.
• Nanoparticle and Liposome Functionalization: Enables the surface modification of drug carriers with targeting ligands, peptides, or imaging agents via the reactive amine group.
• Fluorescent Probe and Diagnostic Reagent Preparation: Used to label biomolecules (proteins, oligonucleotides) with dyes or other reporter molecules for imaging and detection assays.
• Polymer and Biomaterial Modification: Incorporates reactive handles into hydrogels or polymer backbones for subsequent cross-linking or functionalization.

Basic Information

Product Name	Tco-Peg2-Amine
CAS No.	2141981-87-3
Molecular Formula	C₁₉H₃₅NO₄
Molecular Weight	341.49 g/mol
Synonyms	trans-Cyclooctene-PEG2-Amine; TCO-PEG₂-NH₂; (E)-Cyclooct-4-enyl 2,5,8,11-tetraoxatridecan-13-amine; 2,5,8,11-Tetraoxatridecan-13-amine, (E)-cyclooct-4-enyl-; TCO-PEG2-NH2; TCO-amino-PEG2; Amino-PEG2-TCO; TCO-PEG(2)-NH2
EINECS	Contact for details

Quality Control

Our Tco-Peg2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.