Description

[2H5]-Bisoprolol Fumarate CAS NO 2140803-85-4 is a high-purity, stable isotope-labeled analog of the widely used β-blocker, bisoprolol fumarate. This compound is an essential internal standard for the precise and accurate quantification of bisoprolol in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Internal Standard for Bioanalysis: Critical for quantitative LC-MS/MS methods in determining bisoprolol concentrations in plasma, serum, and other biological fluids.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical trials.
• Bioequivalence Testing: Supports regulatory submissions for generic drug development by ensuring precise measurement against the reference listed drug.
• Metabolite Identification and Profiling: Aids in the structural elucidation of bisoprolol metabolites using mass spectrometry.
• Method Development and Validation: Serves as a reliable reference standard for developing and validating robust analytical methods in compliance with GLP and ICH guidelines.
• Quality Control in Manufacturing: Can be used in impurity profiling and stability-indicating assays for bisoprolol fumarate active pharmaceutical ingredient (API).

Basic Information

Item	Detail
Product Name	[2H5]-Bisoprolol Fumarate
CAS No.	2140803-85-4
Molecular Formula	C22H30D5NO8
Molecular Weight	Approx. 452.5 g/mol
Synonyms	Bisoprolol-d5 Fumarate; Deuterated Bisoprolol Fumarate; 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol (2,2,3,3,3-d5) Fumarate; Bisoprolol Fumarate-d5; (RS)-1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol-d5 Fumarate; Bisoprolol (2H5) Fumarate; Isotopically Labeled Bisoprolol Fumarate
EINECS	Contact for details

Quality Control

Every batch of [2H5]-Bisoprolol Fumarate is manufactured under controlled conditions and undergoes stringent analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocol is designed to meet the exacting requirements of analytical and pharmaceutical research. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for isotopic enrichment, chemical purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.