Description

Vortioxetine D8 CAS NO 2140316-62-5 is a deuterated isotopologue of the established antidepressant vortioxetine, where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced drug development and clinical research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of vortioxetine in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based assays to study absorption, distribution, metabolism, and excretion (ADME) profiles.
• Clinical Trial Support: Enables reliable therapeutic drug monitoring and bioequivalence studies during clinical development phases.
• Forensic and Toxicology Analysis: Supports accurate detection and measurement of vortioxetine in forensic investigations.
• Reference Material for Method Development: Serves as a key calibrant in developing and validating robust analytical protocols.
• Isotope Dilution Mass Spectrometry (IDMS): Fundamental for achieving high-precision measurements in research requiring maximal accuracy.

Basic Information

Product Name	Vortioxetine D8
CAS No.	2140316-62-5
Molecular Formula	C18H14D8N2S
Molecular Weight	306.48 g/mol
Synonyms	1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine-d8; Vortioxetine-d8; Brintellix-d8 (labeled); Trintellix-d8 (labeled); Lu AA21004-d8; Deuterated Vortioxetine; Vortioxetine (D8); Vortioxetine Internal Standard
EINECS	Contact for details

Quality Control

Our Vortioxetine D8 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment (D8 content), and purity by HPLC. We adhere to relevant industry guidelines for reference materials to ensure reliable and reproducible performance in sensitive mass spectrometry applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D8)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.