Description

Prucalopride-13Cd3 CAS NO 2140306-00-7 is a stable isotope-labeled analog of Prucalopride, a selective serotonin 5-HT4 receptor agonist. This high-purity reference standard is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for applications in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of Prucalopride in biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used as a reference material to develop, optimize, and validate robust analytical methods compliant with GLP and FDA/EMA guidelines.
• Metabolite Identification & Profiling: Aids in the identification and structural elucidation of Prucalopride metabolites.
• Quality Control in Manufacturing: Supports impurity profiling and quality assurance testing during the active pharmaceutical ingredient (API) manufacturing process.

Basic Information

Product Name	Prucalopride-13Cd3
CAS No.	2140306-00-7
Molecular Formula	C18H23Cl13Cd3N3O3
Molecular Weight	Approx. 434.3 g/mol (Contact for details)
Synonyms	Prucalopride-d3; Prucalopride (13C-labeled); 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide-13Cd3; Resolor-13Cd3; R108512-13Cd3; Motegrity-13Cd3; 5-HT4 Receptor Agonist-13Cd3
EINECS	Contact for details

Quality Control

Our Prucalopride-13Cd3 is manufactured under strict quality control protocols. Each batch undergoes rigorous analytical testing, including HPLC, LC-MS, and NMR, to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic purity, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.