Description

Nilotinib 3-Imidazolyl n-Oxide is a key advanced pharmaceutical intermediate and a derivative of the tyrosine kinase inhibitor nilotinib. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel kinase-targeting therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in oncology drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of nilotinib analogs and next-generation kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of drug candidates.
• Oncology Drug Development: A key reagent in the R&D pipeline for targeted cancer therapies, particularly those inhibiting Bcr-Abl and other kinases.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Applied in biochemical assays to study kinase inhibition mechanisms and cellular signaling pathways.

Basic Information

Product Name	Nilotinib 3-Imidazolyl n-Oxide
CAS No.	2139382-75-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Nilotinib N-Oxide Impurity; Nilotinib Impurity O; 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide 1-Oxide; UNII-6G1V8S35K6; 6G1V8S35K6; Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-yl-2-pyrimidinyl)amino]-, 1-oxide
EINECS	Contact for details

Quality Control

Our Nilotinib 3-Imidazolyl n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The material may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.