Description

1-[3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]-4-Methylpiperazine is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Serves as the organoboron partner for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient carbon-carbon bond formation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex aryl-piperazine motifs.
• Material Science: A building block for creating organic electronic materials, ligands for catalysis, and advanced polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the construction of bifunctional molecules for targeted protein degradation.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	1-[3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]-4-Methylpiperazine
CAS No.	2133421-20-0
Molecular Formula	C17H26BFN2O2
Molecular Weight	320.21 g/mol
Synonyms	4-Methyl-1-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine; 1-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine; 3-Fluoro-4-(4-methylpiperazin-1-yl)phenylboronic acid pinacol ester; 4-Methyl-1-(3-fluoro-4-(pinacolboranyl)phenyl)piperazine; 2133421-20-0; (3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1-[3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]-4-Methylpiperazine is manufactured and tested under strict quality management systems. We guarantee high purity and batch-to-batch consistency to meet the rigorous demands of research and scale-up processes. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.