Description

n-Mal-n-Bis(Peg4-Nh-Boc) is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a Boc-protected amine, linked by a tetraethylene glycol spacer. This compound is engineered for precision bioconjugation, offering controlled reactivity for linking biomolecules such as peptides, proteins, and antibodies. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced drug delivery systems, where stable, site-specific cross-linking is required.

Application

• ADC (Antibody-Drug Conjugate) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• PEGylation of Therapeutic Proteins: Used to introduce PEG chains at specific amine sites to enhance pharmacokinetic properties like solubility and circulation half-life.
• Surface Functionalization: For modifying nanoparticles, biosensors, or microarray slides with maleimide groups for subsequent thiol-based coupling of ligands or probes.
• Cross-linking Reagent: Enables the formation of stable thioether bonds between maleimide and sulfhydryl groups in cysteine-containing peptides or proteins.
• Prodrug Development: Facilitates the creation of enzyme-cleavable prodrug constructs where the Boc-protected amine allows for further functionalization.
• Biomaterial Engineering: Incorporation into hydrogels or polymer scaffolds to create bioactive materials for tissue engineering and controlled release applications.

Basic Information

Product Name	n-Mal-n-Bis(Peg4-Nh-Boc)
CAS No.	2128735-27-1
Molecular Formula	C31H54N2O13
Molecular Weight	662.77 g/mol
Synonyms	Maleimide-PEG4-amine-Boc; Boc-NH-PEG4-maleimide; 1-Boc-amino-3,6,9,12-tetraoxapentadecan-15-yl maleimide; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoate; Boc-Amino-PEG4-MAL; Heterobifunctional PEG linker MAL-PEG4-NH-Boc; N-(Boc-amino)-PEG4-maleimide
EINECS	Contact for details

Quality Control

Every batch of n-Mal-n-Bis(Peg4-Nh-Boc) is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and functional group integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, ensuring compliance with research and cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.