Description

Clindamycin Palmitate Sulfoxide Hydrochloride is a chemically modified derivative of the lincosamide antibiotic clindamycin, specifically designed for enhanced stability and specific pharmaceutical research applications. This compound is critical for the development and quality control of antibiotic formulations, serving as a key reference standard and intermediate. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the production of advanced antibiotic products.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of clindamycin-based drug products in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial synthetic precursor in the manufacturing process of specialized clindamycin derivatives.
• Metabolite and Impurity Studies: Employed in analytical research to study the degradation pathways, metabolism, and stability profiles of clindamycin palmitate hydrochloride.
• Method Development and Validation: Essential for developing and validating precise analytical methods, such as HPLC and LC-MS, for antibiotic analysis.
• Regulatory Compliance and Documentation: Supports regulatory filings (e.g., with FDA, EMA) by providing characterized material for stability studies and impurity identification.
• Academic and Clinical Research: Used in university and institutional research to investigate the structure-activity relationships and novel applications of lincosamide antibiotics.

Basic Information

Product Name	Clindamycin Palmitate Sulfoxide Hydrochloride
CAS No.	2126928-92-3
Molecular Formula	C34H63ClN2O7S
Molecular Weight	679.40 g/mol
Synonyms	Clindamycin Palmitate S-Oxide Hydrochloride; Clindamycin Palmitate Sulfoxide HCl; (2S,4R)-N-[(1S,2S)-2-Chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfinyl)oxan-2-yl]propyl]-1-methyl-4-propyl-N-[(2S,3R,4S,5S)-3,4,5-tris(palmitoyloxy)oxan-2-yl]pyrrolidine-2-carboxamide hydrochloride; Lincocin Palmitate Sulfoxide Hydrochloride; 7(S)-Chloro-7-deoxylincomycin Palmitate Sulfoxide Hydrochloride
EINECS	Contact for details

Quality Control

Our Clindamycin Palmitate Sulfoxide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. Certificates of Analysis (COA) detailing all test results against established specifications are provided to ensure traceability and compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.