Description

7-Hydroxy Granisetron-D3 Hydrochloride is a deuterium-labeled internal standard critical for the precise quantification of its parent compound, Granisetron, in complex biological matrices. This high-purity reference material is essential for ensuring the accuracy and reliability of pharmacokinetic and bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in method development and validation for antiemetic drugs.

Application

• Bioanalytical Method Development: Serves as a stable isotope-labeled internal standard for the quantification of Granisetron and its metabolites in plasma, serum, and urine via LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical trials.
• Drug Metabolism Studies: Used to investigate the metabolic pathways and clearance mechanisms of Granisetron.
• Quality Control in Manufacturing: Supports impurity profiling and assay validation for Granisetron active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Doping Control Analysis: Provides a definitive reference for confirmatory testing in specialized toxicology screens.

Basic Information

Product Name	7-Hydroxy Granisetron-D3 Hydrochloride
CAS No.	2124272-03-1
Molecular Formula	C18H21D3N4O•HCl
Molecular Weight	348.86 g/mol (for monoisotopic)
Synonyms	1-Methyl-N-((1R,3r,5S)-9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide-7-hydroxy-d3 Hydrochloride; Granisetron-7-hydroxy-d3 HCl; Deuterated 7-Hydroxy Granisetron Hydrochloride; 1H-Indazole-3-carboxamide, 1-methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]non-3-yl)-7-hydroxy-, hydrochloride, labeled with deuterium; Granisetron Metabolite D3 Standard
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Granisetron-D3 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/MS for structural confirmation and isotopic enrichment verification, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.