Description

4-(Benzyloxy)-2,3-Difluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound matters for its role as a protected boronic acid derivative, offering enhanced stability and handling characteristics for critical cross-coupling reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring difluorinated biphenyl or aryl ether structures.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating fluorinated aromatic cores in electronic and display materials.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and ligands where the benzyl-protected boronate ester functionality is required.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new catalytic processes and complex molecule synthesis.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis due to its improved stability compared to the corresponding boronic acid.

Basic Information

Item	Details
Product Name	4-(Benzyloxy)-2,3-Difluorophenylboronic Acid Pinacol Ester
CAS No.	2121515-12-4
Molecular Formula	C19H21BF2O3
Molecular Weight	346.18 g/mol
Synonyms	4-(Benzyloxy)-2,3-difluorophenylboronic acid pinacol ester; 2,3-Difluoro-4-(phenylmethoxy)benzeneboronic acid pinacol ester; [4-(Benzyloxy)-2,3-difluorophenyl]boronic acid pinacol ester; 4-(Benzyloxy)-2,3-difluorobenzeneboronic acid pinacol ester; Pinacol [4-(benzyloxy)-2,3-difluorophenyl]boronate; B-[4-(Benzyloxy)-2,3-difluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxy)-2,3-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.