Description

4-Chloro-3-Fluoro-2-Methoxyphenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its primary value lies in its role as a versatile building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro-methoxy substitution pattern imparts specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as polymers for OLEDs and sensors.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis and organoboron reagents.
• Chemical Biology Probes: Utilized to create tagged molecules or affinity probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-Chloro-3-Fluoro-2-Methoxyphenylboronic Acid
CAS No.	2121515-10-2
Molecular Formula	C7H7BClFO3
Molecular Weight	203.39 g/mol
Synonyms	(4-Chloro-3-fluoro-2-methoxyphenyl)boronic acid; 2-Methoxy-4-chloro-3-fluorophenylboronic acid; 4-Chloro-3-fluoro-2-methoxybenzeneboronic acid; Boronic acid, B-(4-chloro-3-fluoro-2-methoxyphenyl)-; CAS 2121515-10-2
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Fluoro-2-Methoxyphenylboronic Acid is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure compliance with exacting purity standards suitable for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.