Description

2-Chloro-3,4-Difluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block, essential for modern cross-coupling reactions. Its core value lies in enabling the precise and efficient construction of complex molecules, particularly in the development of active pharmaceutical ingredients and advanced materials. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to construct biaryl and heterobiaryl scaffolds prevalent in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel active pharmaceutical ingredients (APIs), especially those containing difluorophenyl and chlorophenyl motifs.
• Agrochemical Research: Serves as a building block for creating new herbicides, fungicides, and insecticides with enhanced properties.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials for electronic devices.
• Chemical Biology & Probe Development: Useful for labeling and modifying biomolecules or creating chemical probes for biological target identification.
• Scale-up Process Chemistry: Suitable for transition from laboratory-scale research to pilot plant and commercial manufacturing due to its stability as a pinacol ester.

Basic Information

Product Name	2-Chloro-3,4-Difluorophenylboronic Acid Pinacol Ester
CAS No.	2121515-05-5
Molecular Formula	C12H14BClF2O2
Molecular Weight	274.50 g/mol
Synonyms	2-Chloro-3,4-difluorophenylboronic acid pinacol ester; (2-Chloro-3,4-difluorophenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2-chloro-3,4-difluorophenyl)-1,3,2-dioxaborolane; 2-(2-Chloro-3,4-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-Chloro-3,4-difluorophenyl)boronate; Boronic acid, B-(2-chloro-3,4-difluorophenyl)-, 1,1-dimethylethyl ester; 2-Chloro-3,4-difluorophenyl-Bpin
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,4-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent hydrolysis and oxidation. Keep away from strong acids and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.