Description

6-Bromo-3-Chloro-2,4-Difluorophenylboronic Acid Pinacol Ester is a high-purity, multi-halogenated boronic ester building block essential for modern synthetic chemistry. Its value lies in its stability and versatility as a key intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting complex, halogenated aromatic scaffolds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the specific halogen pattern can influence bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs), liquid crystals, and other advanced electronic materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for client projects.

Basic Information

Product Name	6-Bromo-3-Chloro-2,4-Difluorophenylboronic Acid Pinacol Ester
CAS No.	2121515-01-1
Molecular Formula	C₁₂H₁₃BBrClF₂O₂
Molecular Weight	353.40 g/mol
Synonyms	(6-Bromo-3-chloro-2,4-difluorophenyl)boronic acid pinacol ester; 2-(6-Bromo-3-chloro-2,4-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-Bromo-3-chloro-2,4-difluorobenzeneboronic acid pinacol ester; Pinacol (6-bromo-3-chloro-2,4-difluorophenyl)boronate; Boronic acid, B-(6-bromo-3-chloro-2,4-difluorophenyl)-, 1,1-dimethylethyl ester (9CI); 6-Bromo-3-chloro-2,4-difluorophenyl-Bpin; CAS 2121515-01-1
EINECS	Contact for details

Quality Control

Our 6-Bromo-3-Chloro-2,4-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.