Description

4-Benzyloxy-5-Chloro-2-Fluorophenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce complex aryl groups with specific substitution patterns.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially those targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: A crucial reagent for forming carbon-carbon bonds to construct biaryl systems, a common scaffold in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides and fungicides with enhanced efficacy and selectivity.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology Probes: Enables the synthesis of labeled compounds and molecular probes for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: An essential starting material for CDMOs and fine chemical suppliers producing bespoke compounds for client projects.

Basic Information

Product Name	4-Benzyloxy-5-Chloro-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	2121514-89-2
Molecular Formula	C19H21BClFO3
Molecular Weight	377.63 g/mol
Synonyms	5-Chloro-2-fluoro-4-(phenylmethoxy)benzeneboronic acid pinacol ester; 4-(Benzyloxy)-5-chloro-2-fluorophenylboronic acid pinacol ester; (4-(Benzyloxy)-5-chloro-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-5-chloro-4-benzyloxyphenylboronic acid pinacol ester; B-[4-(Benzyloxy)-5-chloro-2-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2121514-89-2; 4-Benzyloxy-5-chloro-2-fluorobenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-5-Chloro-2-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.