Description

2,5-Difluoro-4-Benzyloxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound matters for its role as a key intermediate in modern cross-coupling reactions, enabling the precise construction of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting fluorinated bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the difluoro and benzyloxy substituents can impart desirable biological activity and stability.
• Material Science Research: Serves as a precursor for creating functionalized organic frameworks, liquid crystals, or polymers with specific electronic or optical properties.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules or probes for studying biological processes, leveraging the boronic ester's reactivity for bioconjugation.
• Process Chemistry Development: Used for scaling up synthetic routes in pilot plants and commercial manufacturing, where consistent quality and reliable supply are paramount.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting fundamental research in synthetic organic chemistry and methodology development.

Basic Information

Product Name	2,5-Difluoro-4-Benzyloxyphenylboronic Acid Pinacol Ester
CAS No.	2121514-83-6
Molecular Formula	C19H21BF2O3
Molecular Weight	346.18 g/mol
Synonyms	4-(Benzyloxy)-2,5-difluorophenylboronic acid pinacol ester; (4-(Benzyloxy)-2,5-difluorophenyl)boronic acid pinacol ester; 2,5-Difluoro-4-(phenylmethoxy)benzeneboronic acid pinacol ester; B-[4-(Benzyloxy)-2,5-difluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[4-(phenylmethoxy)-2,5-difluorophenyl]-1,3,2-dioxaborolane; 2,5-Difluoro-4-benzyloxybenzeneboronic acid pinacol ester; PINACOL 2,5-DIFLUORO-4-BENZYLOXYPHENYLBORONATE
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Benzyloxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.