Description

2-Isopropoxy-4-(Trifluoromethyl)Phenylboronic Acid, Pinacol Ester is a high-value, protected boronic acid derivative, also known as a boronate ester, designed for advanced synthetic chemistry. This compound is a critical building block in cross-coupling reactions, offering enhanced stability and handling compared to its free boronic acid counterpart. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules containing the 2-isopropoxy-4-(trifluoromethyl)phenyl moiety.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds, essential in constructing biaryl structures common in active pharmaceutical ingredients (APIs) and advanced materials.
• Pharmaceutical Intermediate Synthesis: Serves as a versatile building block for creating drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that benefit from the chemical and metabolic stability imparted by the trifluoromethyl and isopropoxy groups.
• Material Science Precursor: Employed in the development of organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Useful for creating tagged molecules or chemical probes for studying biological pathways and protein interactions.

Basic Information

Product Name	2-Isopropoxy-4-(Trifluoromethyl)Phenylboronic Acid, Pinacol Ester
CAS No.	2121513-99-1
Molecular Formula	C16H22BF3O3
Molecular Weight	330.15 g/mol
Synonyms	2-Isopropoxy-4-(trifluoromethyl)benzeneboronic acid pinacol ester; 4-(Trifluoromethyl)-2-isopropoxyphenylboronic acid pinacol ester; [2-Isopropoxy-4-(trifluoromethyl)phenyl]boronic acid pinacol ester; Pinacol [2-isopropoxy-4-(trifluoromethyl)phenyl]boronate; 2-(Isopropoxy)-4-(trifluoromethyl)phenylboronic acid pinacol ester; Boronic acid, B-[2-isopropoxy-4-(trifluoromethyl)phenyl]-, 1,1,1-trimethylethylene ester; CAS 2121513-99-1
EINECS	Contact for details

Quality Control

Our 2-Isopropoxy-4-(Trifluoromethyl)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.