Description

4-Fluoro-3-Formyl-5-Methylphenylboronic Acid Pinacol Ester is a sophisticated, multi-functional organoboron building block essential for modern synthetic chemistry. Its value lies in the strategic combination of a protected boronic acid group, a formyl aldehyde, and a fluorine substituent on a methylated aromatic ring, enabling precise and complex molecular construction. This compound is critically needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in drug candidates targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by incorporating the fluorinated, formyl-substituted phenyl moiety into active molecules.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its planar, functionalized structure.
• Chemical Biology Probes: Utilized to develop fluorescent tags and molecular probes for studying biological processes and enzyme activity.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	4-Fluoro-3-Formyl-5-Methylphenylboronic Acid Pinacol Ester
CAS No.	2121513-83-3
Molecular Formula	C15H20BFO3
Molecular Weight	278.13 g/mol
Synonyms	4-Fluoro-3-formyl-5-methylbenzeneboronic acid pinacol ester; (4-Fluoro-3-formyl-5-methylphenyl)boronic acid pinacol ester; 2-(4-Fluoro-3-formyl-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Fluoro-4-formyl-2-methylphenylboronic acid pinacol ester; Boronic acid, B-(4-fluoro-3-formyl-5-methylphenyl)-, 1,1-dimethylethyl ester (9CI); CAS 2121513-83-3
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-Formyl-5-Methylphenylboronic Acid Pinacol Ester is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and advanced synthesis. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles by HPLC, NMR, and LC-MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.