Description

2-Hydroxymethyl-5-(Trifluoromethyl)Phenylboronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a hydroxymethyl and a trifluoromethyl group on the phenyl ring, makes it an essential reagent for constructing complex molecules with tailored properties. This compound is primarily sought after by research scientists and process chemists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the phenylboronic acid moiety facilitates carbon-carbon bond formation.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile coupling partner with aryl/vinyl halides to form biaryl structures, a fundamental reaction in medicinal and process chemistry.
• Medicinal Chemistry & Drug Discovery: Utilized in high-throughput screening and the synthesis of compound libraries for identifying new drug candidates.
• Chemical Biology Probes: Acts as a precursor for synthesizing molecules used to study biological processes and protein interactions.

Basic Information

Product Name	2-Hydroxymethyl-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	2121513-82-2
Molecular Formula	C8H8BF3O3
Molecular Weight	219.96 g/mol
Synonyms	[2-(Hydroxymethyl)-5-(trifluoromethyl)phenyl]boronic acid; (2-Hydroxymethyl-5-trifluoromethylphenyl)boronic acid; 5-(Trifluoromethyl)-2-(hydroxymethyl)benzeneboronic acid; 2-(Hydroxymethyl)-α,α,α-trifluoro-m-tolylboronic acid; Boronic acid, B-[2-(hydroxymethyl)-5-(trifluoromethyl)phenyl]-; m-Trifluoromethyl-2-hydroxymethylphenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Hydroxymethyl-5-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.