Description

4,5-Difluro-2-Ethoxyphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical advanced pharmaceutical intermediate, enabling the construction of complex molecular architectures through cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking reliable, high-quality building blocks for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly those requiring difluorinated and ethoxy-substituted aromatic systems.
• Agrochemical Synthesis: Serves as a building block for creating new herbicides, fungicides, and insecticides with enhanced properties.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and materials science applications.
• Organic Electronic Materials: A potential precursor for the synthesis of fluorinated organic semiconductors and light-emitting materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	4,5-Difluro-2-Ethoxyphenylboronic Acid Pinacol Ester
CAS No.	2121513-79-7
Molecular Formula	C₁₄H₁₉BF₂O₃
Molecular Weight	284.11 g/mol
Synonyms	2-Ethoxy-4,5-difluorophenylboronic acid pinacol ester; 4,5-Difluoro-2-ethoxyphenylboronic acid pinacol ester; (4,5-Difluoro-2-ethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(4,5-Difluoro-2-ethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,5-Difluoro-2-ethoxybenzeneboronic acid pinacol ester; Pinacol (4,5-difluoro-2-ethoxyphenyl)boronate
EINECS	Contact for details

Quality Control

Every batch of 4,5-Difluro-2-Ethoxyphenylboronic Acid Pinacol Ester is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets the exacting standards for research and process chemistry. Our quality commitment supports applications requiring high-purity intermediates for regulatory filings and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.