Description

5-Chloro-2-Fluoro-4-Isopropoxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical protected boronic acid building block, enabling efficient cross-coupling reactions in complex molecule assembly. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides requiring specific halogenated aromatic structures.
• Material Science Research: Building block for creating organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: The pinacol ester group offers improved stability and handling properties compared to the free boronic acid, facilitating larger-scale manufacturing processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring this specific halogenated arylboronate.

Basic Information

Product Name	5-Chloro-2-Fluoro-4-Isopropoxyphenylboronic Acid Pinacol Ester
CAS No.	2121513-71-9
Molecular Formula	C15H21BClFO3
Molecular Weight	314.59 g/mol
Synonyms	5-Chloro-2-fluoro-4-isopropoxyphenylboronic acid pinacol ester; 4-Isopropoxy-5-chloro-2-fluorophenylboronic acid pinacol ester; (5-Chloro-2-fluoro-4-isopropoxyphenyl)boronic acid pinacol ester; 2-(5-Chloro-2-fluoro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2-fluoro-4-(1-methylethoxy)benzeneboronic acid pinacol ester; Boronic acid, B-(5-chloro-2-fluoro-4-isopropoxyphenyl)-, 1,1,1',1'-tetramethyl-2,2'-bi-1,3,2-benzodioxaborole
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-4-Isopropoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive coupling reactions. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and filing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.