Description

5-Chloro-4-Ethoxy-2-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures critical in modern organic synthesis. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those containing complex fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where specific halogenated biphenyl motifs are required.
• Material Science: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Research: Employed in academic and industrial laboratories for methodological development in palladium-catalyzed cross-coupling reactions.
• API Development: Integral to constructing the core scaffolds of potential therapeutic agents targeting various diseases.
• Custom Synthesis: Provides a versatile handle for contract research and manufacturing organizations (CROs/CMOs) to produce bespoke compounds for clients.

Basic Information

Product Name	5-Chloro-4-Ethoxy-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	2121513-68-4
Molecular Formula	C₁₄H₁₉BClFO₃
Molecular Weight	300.56 g/mol
Synonyms	5-Chloro-4-ethoxy-2-fluorophenylboronic acid pinacol ester; (5-Chloro-4-ethoxy-2-fluorophenyl)boronic acid pinacol ester; 2-(5-Chloro-4-ethoxy-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Ethoxy-5-chloro-2-fluorophenylboronic acid pinacol ester; Pinacol (5-chloro-4-ethoxy-2-fluorophenyl)boronate; Boronic acid, B-(5-chloro-4-ethoxy-2-fluorophenyl)-, 1,1-dimethylethyl ester (9CI); CAS 2121513-68-4
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Ethoxy-2-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.