Description

5-Chloro-2-Fluoro-4-Hydroxyphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides requiring specific halogenated phenyl motifs.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and sensors.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules due to the selective reactivity of the protected boronate group.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel ligands used in asymmetric catalysis.
• Custom Synthesis & Contract Manufacturing: A vital raw material for CROs and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	5-Chloro-2-Fluoro-4-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	2121513-66-2
Molecular Formula	C12H15BClFO3
Molecular Weight	271.51 g/mol
Synonyms	5-Chloro-2-fluoro-4-hydroxyphenylboronic acid pinacol ester; (5-Chloro-2-fluoro-4-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(5-Chloro-2-fluoro-4-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Hydroxy-5-chloro-2-fluorophenylboronic acid pinacol ester; Pinacol (5-chloro-2-fluoro-4-hydroxyphenyl)boronate; Boronic acid, B-(5-chloro-2-fluoro-4-hydroxyphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoro-4-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.