Description

3-Chloro-6-Fluoro-2-Methoxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected boronic acid building block, offering enhanced stability and handling characteristics for advanced cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex, halogen-substituted aromatic target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing novel drug candidates, particularly those containing di-substituted (chloro and fluoro) aryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that require specific halogenated aromatic structures.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or charge-transport materials, where the methoxy and halogen groups tune electronic properties.
• Chemical Biology Probes: Acts as a building block for creating labeled molecules or bioconjugates used in proteomics and diagnostic assay development.
• Process Chemistry: The pinacol ester protection offers improved shelf-life and purity for scalable manufacturing processes compared to the corresponding free boronic acid.
• Academic & Contract Research: A valuable reagent for methodology development in synthetic organic chemistry laboratories focusing on C-C bond formation.

Basic Information

Item	Detail
Product Name	3-Chloro-6-Fluoro-2-Methoxyphenylboronic Acid Pinacol Ester
CAS No.	2121513-63-9
Molecular Formula	C₁₃H₁₇BClFO₃
Molecular Weight	286.53 g/mol
Synonyms	3-Chloro-6-fluoro-2-methoxyphenylboronic acid pinacol ester; (3-Chloro-6-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Methoxy-3-chloro-6-fluorophenylboronic acid pinacol ester; 3-Chloro-6-fluoro-2-methoxybenzeneboronic acid pinacol ester; Boronic acid, B-(3-chloro-6-fluoro-2-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI); 3-Chloro-6-fluoro-2-methoxy phenylboronic acid pinacol ester; CAS 2121513-63-9
EINECS	Contact for details

Quality Control

Our 3-Chloro-6-Fluoro-2-Methoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for cGMP intermediate production and REACH compliance for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent hydrolysis and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.