Description

3-Bromo-2,6-Difluorophenylboronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative, essential for modern cross-coupling reactions. Its core value lies in providing a stable, reactive handle for the precise construction of complex molecules, particularly in pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing complex biaryl and heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection, leveraging its difluorinated and brominated phenyl ring for bioactivity.
• Material Science Research: Serves as a building block for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) where precise molecular architecture is required.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: The pinacol ester group offers enhanced stability compared to the free boronic acid, making it suitable for multi-step synthesis and larger-scale manufacturing processes.

Basic Information

Product Name	3-Bromo-2,6-Difluorophenylboronic Acid Pinacol Ester
CAS No.	2121513-51-5
Molecular Formula	C₁₂H₁₄BBrF₂O₂
Molecular Weight	319.0 g/mol
Synonyms	3-Bromo-2,6-difluorophenylboronic acid pinacol ester; (3-Bromo-2,6-difluorophenyl)boronic acid pinacol ester; 2-(3-Bromo-2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-2,6-difluorophenyl-Bpin; B-(3-Bromo-2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-bromo-2,6-difluorophenyl)boronate; CAS 2121513-51-5
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,6-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to consistent quality and traceability supports your research and development needs from discovery to scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.