Description

5-Bromo-2,3-Difluoro-4-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected boronic acid intermediate, offering enhanced stability for handling and storage compared to its free acid form. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions, a fundamental method for constructing complex biaryl and heterobiaryl scaffolds central to modern drug discovery and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex difluorinated and brominated aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the specific halogenated pattern can influence biological activity.
• Material Science Research: Employed in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, via cross-coupling polymerization.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands or functionalized molecules used in catalysis and molecular recognition.
• Chemical Biology Probes: Useful for constructing tagged molecules or bioconjugates for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to custom synthesis organizations (CSOs) and CDMOs for use in client-directed projects requiring this specific molecular fragment.

Basic Information

Product Name	5-Bromo-2,3-Difluoro-4-Methylphenylboronic Acid Pinacol Ester
CAS No.	2121513-43-5
Molecular Formula	C13H16BBrF2O2
Molecular Weight	333.98 g/mol
Synonyms	5-Bromo-2,3-difluoro-4-methylbenzeneboronic acid pinacol ester; 2-(5-Bromo-2,3-difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Bromo-2,3-difluoro-p-tolylboronic acid pinacol ester; (5-Bromo-2,3-difluoro-4-methylphenyl)boronic acid pinacol ester; B-(5-Bromo-2,3-difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2121513-43-5; Pinacol (5-Bromo-2,3-difluoro-4-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,3-Difluoro-4-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. We provide comprehensive analytical data including HPLC purity, NMR (1H, 13C, 19F, 11B) confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting all relevant specifications. Our quality system is designed to support cGMP and ISO-guided applications where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.