Description

2,4-Difluoro-6-Bromophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing complex, fluorinated and halogenated biaryl structures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl and bromophenyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the specific halogen and fluorine substitution pattern is required for bioactivity.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as ligands for OLEDs or monomers for specialty polymers.
• Chemical Biology & Probe Development: Employed in the construction of molecular probes and tags for studying biological systems, leveraging its boronic ester functionality.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring precise, scalable coupling reactions.

Basic Information

Product Name	2,4-Difluoro-6-Bromophenylboronic Acid Pinacol Ester
CAS No.	2121513-38-8
Molecular Formula	C12H14BBrF2O2
Molecular Weight	303.0 g/mol
Synonyms	2,4-Difluoro-6-bromophenylboronic acid pinacol ester; (2-Bromo-3,5-difluorophenyl)boronic acid pinacol ester; 2-Bromo-3,5-difluorophenylboronic acid pinacol ester; Pinacol (2-bromo-3,5-difluorophenyl)boronate; (2-Bromo-3,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(2-bromo-3,5-difluorophenyl)-1,3,2-dioxaborolane; B-(2-Bromo-3,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-6-Bromophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.