Description

2-(2,3-Dichloro-6-Fluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where it enables efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is specifically designed for researchers and process chemists in R&D and manufacturing who require reliable, high-quality reagents to accelerate drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex biaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated aromatic motifs.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl bonds, a fundamental transformation in medicinal chemistry.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for biological target identification and validation.
• Custom Synthesis & Contract Manufacturing: An essential reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies producing bespoke compounds for clients.

Basic Information

Product Name	2-(2,3-Dichloro-6-Fluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2121513-26-4
Molecular Formula	C₁₃H₁₆BCl₂FO₂
Molecular Weight	319.98 g/mol
Synonyms	2,3-Dichloro-6-fluoro-4-methylbenzeneboronic acid pinacol ester; (2,3-Dichloro-6-fluoro-4-methylphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[2,3-dichloro-6-fluoro-4-methylphenyl]-1,3,2-dioxaborolane; 2-(2,3-Dichloro-6-fluoro-p-tolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2,3-Dichloro-6-fluoro-4-methylphenylboronic acid pinacol ester; CAS 2121513-26-4
EINECS	Contact for details

Quality Control

Our 2-(2,3-Dichloro-6-Fluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including NMR, HPLC, and GC-MS, to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.