Description

2-Chloro-6-Fluoro-3-Hydroxyphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected intermediate in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting complex aromatic scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific halogenated biaryl motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Suzuki-Miyaura Cross-Coupling: Acts as a stable, air-handleable boronate reagent for palladium-catalyzed carbon-carbon bond formation with various aryl halides.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological processes and target engagement.

Basic Information

Product Name	2-Chloro-6-Fluoro-3-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	2121512-89-6
Molecular Formula	C12H15BClFO3
Molecular Weight	271.51 g/mol
Synonyms	(2-Chloro-6-fluoro-3-hydroxyphenyl)boronic acid pinacol ester; 2-Chloro-6-fluoro-3-hydroxybenzeneboronic acid pinacol ester; Pinacol (2-chloro-6-fluoro-3-hydroxyphenyl)boronate; 2-Chloro-6-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; B-(2-Chloro-6-fluoro-3-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-(2-chloro-6-fluoro-3-hydroxyphenyl)-, 1,1-dimethylethyl ester; CAS 2121512-89-6
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoro-3-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.