Description

2-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, serving as a critical protected intermediate in modern cross-coupling chemistry. Its primary value lies in enabling the controlled introduction of the 2-chloro-5-(trifluoromethoxy)phenyl moiety into complex molecular architectures, a key step in developing advanced materials and active pharmaceutical ingredients. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries who require reliable, high-quality building blocks for Suzuki-Miyaura and other palladium-catalyzed reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethoxy and chloro-substituted aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the specific substitution pattern contributes to product efficacy and environmental profile.
• Material Science: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, where precise molecular structure controls performance.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Chemical Biology & Probe Design: Utilized in the construction of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global client projects.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester
CAS No.	2121512-77-2
Molecular Formula	C₁₃H₁₅BClF₃O₃
Molecular Weight	322.52 g/mol
Synonyms	2-Chloro-5-(trifluoromethoxy)benzeneboronic acid pinacol ester; [2-Chloro-5-(trifluoromethoxy)phenyl]boronic acid pinacol ester; 2-Chloro-5-(trifluoromethoxy)phenylboronic acid neopentyl glycol ester (common alternative); (2-Chloro-5-(trifluoromethoxyphenyl))-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [2-Chloro-5-(trifluoromethoxy)phenyl]boronate; 2-Chloro-5-(trifluoromethoxy)phenyl-Bpin; CAS 2121512-77-2
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specification results is provided with each shipment, supporting your regulatory and quality documentation needs for R&D and cGMP (current Good Manufacturing Practice) applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.