Description

2,4-Difluoro-3-Formylphenylboronic Acid Pinacol Ester is a high-value, multifunctional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct novel, fluorinated herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced organic electronic materials, such as OLEDs and OFETs.
• Ligand and Catalyst Development: Employed in the creation of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Polymer Chemistry: Incorporated into polymer backbones via cross-coupling to create specialty polymers with tailored optical or electronic properties.

Basic Information

Item	Detail
Product Name	2,4-Difluoro-3-Formylphenylboronic Acid Pinacol Ester
CAS No.	2121512-76-1
Molecular Formula	C14H17BF2O3
Molecular Weight	282.10 g/mol
Synonyms	2,4-Difluoro-3-formylbenzeneboronic acid pinacol ester; (3-Formyl-2,4-difluorophenyl)boronic acid pinacol ester; 2-(2,4-Difluoro-3-formylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2,4-Difluoro-3-formylphenylboronic acid, pinacol ester; 3-Formyl-2,4-difluorophenylboronic acid pinacol ester; Boronic acid, B-(3-formyl-2,4-difluorophenyl)-, 1,1,1',1'-tetramethyl-2,2'-bi-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Formylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency essential for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach ambient temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.