Description

4-Benzyloxy-5-Chloro-2-Fluorophenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing complex biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated biphenyl structures.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and drug discovery.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Benzyloxy-5-Chloro-2-Fluorophenylboronic Acid
CAS No.	2121512-45-4
Molecular Formula	C13H11BClFO3
Molecular Weight	279.49 g/mol
Synonyms	5-Chloro-2-fluoro-4-(phenylmethoxy)benzeneboronic acid; (4-(Benzyloxy)-5-chloro-2-fluorophenyl)boronic acid; 4-Benzyloxy-5-chloro-2-fluorobenzeneboronic acid; B-(4-Benzyloxy-5-chloro-2-fluorophenyl)boronic acid; 2121512-45-4; AKOS026712293; A1-00396
EINECS	Contact for details

Quality Control

Every batch of 4-Benzyloxy-5-Chloro-2-Fluorophenylboronic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent lot-to-lot performance suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.