Description

2,5-Difluoro-4-Ethoxyphenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound matters for its role as a key Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex biaryl structures critical in modern chemistry. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-tolerant boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to create complex, fluorinated biaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoro and ethoxy substituents can modulate biological activity and stability.
• Material Science & OLED Development: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and light-emitting materials for electronic displays and devices.
• Chemical Biology & Probe Development: Useful for creating fluorinated molecular probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	2,5-Difluoro-4-Ethoxyphenylboronic Acid Pinacol Ester
CAS No.	2121512-38-5
Molecular Formula	C14H19BF2O3
Molecular Weight	284.11 g/mol
Synonyms	2,5-Difluoro-4-ethoxyphenylboronic acid pinacol ester; 4-Ethoxy-2,5-difluorophenylboronic acid pinacol ester; (2,5-Difluoro-4-ethoxyphenyl)boronic acid pinacol ester; 2,5-Difluoro-4-ethoxybenzeneboronic acid pinacol ester; Pinacol (2,5-difluoro-4-ethoxyphenyl)boronate; 2,5-Difluoro-4-ethoxybenzeneboronic acid, pinacol ester; Boronic acid, B-(2,5-difluoro-4-ethoxyphenyl)-, 1,1,1',1'-tetramethyl-2,2'-bi-1,3,2-benzodioxaborole
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Ethoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to consistent quality and traceability supports cGMP (current Good Manufacturing Practice) compliance for advanced intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.