Description

2,6-Difluoro-3-Hydroxymethylphenylboronic Acid is a high-value boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular structure, featuring both boronic acid and hydroxymethyl functional groups on a difluorinated aromatic ring, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and other catalytic processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and hydroxymethyl groups contribute to biological activity and metabolic stability.
• Material Science Research: Employed in the creation of advanced organic materials, including ligands for catalysts, organic semiconductors, and monomers for specialty polymers.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of molecular probes and inhibitors due to its boronic acid moiety's affinity for diols.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects and scale-up production for clinical trial materials.

Basic Information

Product Name	2,6-Difluoro-3-Hydroxymethylphenylboronic Acid
CAS No.	2121512-29-4
Molecular Formula	C7H7BF2O3
Molecular Weight	187.94 g/mol
Synonyms	(3-(Hydroxymethyl)-2,6-difluorophenyl)boronic Acid; 2,6-Difluoro-3-(hydroxymethyl)benzeneboronic Acid; 3-(Boronyl)-2,6-difluorobenzyl Alcohol; 2,6-Difluoro-3-(hydroxymethyl)phenylboronic Acid; B-(3-(Hydroxymethyl)-2,6-difluorophenyl)boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,6-Difluoro-3-Hydroxymethylphenylboronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.