Description

2-Chloro-3-Fluoro-4-(Hydroxymethyl)Phenylboronic Acid is a high-value, multi-functional boronic acid derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides requiring specific halogenated phenyl motifs.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where its boronic acid group facilitates polymerization or functionalization.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design of molecular probes and sensors that leverage boronic acid-diol interactions for detection applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific halogenated boronic acid.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-(Hydroxymethyl)Phenylboronic Acid
CAS No.	2121512-25-0
Molecular Formula	C7H7BClFO3
Molecular Weight	203.39 g/mol
Synonyms	(2-Chloro-3-fluoro-4-(hydroxymethyl)phenyl)boronic acid; 2-Chloro-3-fluoro-4-(hydroxymethyl)benzeneboronic acid; 4-Borono-2-chloro-3-fluorobenzyl alcohol; [2-Chloro-3-fluoro-4-(hydroxymethyl)phenyl]boronic acid; B-[2-Chloro-3-fluoro-4-(hydroxymethyl)phenyl]boronic acid; 2-Chloro-3-fluoro-4-(hydroxymethyl)phenyl-Boronic Acid; (2-Chloro-3-fluoro-4-methylolphenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoro-4-(Hydroxymethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.