Description

6-Bromo-2-Fluoro-3-Iodophenylboronic Acid Pinacol Ester is a high-value, multi-halogenated boronic ester derivative, serving as a critical synthetic intermediate in modern cross-coupling chemistry. Its unique halogen substitution pattern (Br, F, I) on the aromatic ring provides exceptional versatility for sequential, site-selective functionalization, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in pharmaceutical development, agrochemical discovery, and advanced materials science, where precise molecular editing is required.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially in oncology and CNS drug candidates.
• Agrochemical Synthesis: Used to create complex, halogenated aromatic structures found in modern herbicides, fungicides, and insecticides.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLEDs and semiconductors, where halogenated aromatics tune electronic properties.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	6-Bromo-2-Fluoro-3-Iodophenylboronic Acid Pinacol Ester
CAS No.	2121512-15-8
Molecular Formula	C12H14BBrFIO2
Molecular Weight	438.86 g/mol
Synonyms	2-Bromo-6-Fluoro-3-Iodophenylboronic Acid Pinacol Ester; (6-Bromo-2-Fluoro-3-Iodophenyl)boronic Acid Pinacol Ester; 4-Bromo-2-Fluoro-5-Iodophenylboronic Acid Pinacol Ester; B-(6-Bromo-2-Fluoro-3-Iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 6-Bromo-2-Fluoro-3-Iodobenzeneboronate; CAS 2121512-15-8
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Fluoro-3-Iodophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected by pharmaceutical and advanced R&D customers, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.