Description

2-Benzyloxy-4,5-Difluorophenylboronic Acid is a high-value, synthetically versatile boronic acid derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in constructing advanced herbicide and pesticide molecules, where the difluorophenyl moiety can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and as a building block for functional materials.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as polymers for OLEDs and sensors.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and affinity tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	2-Benzyloxy-4,5-Difluorophenylboronic Acid
CAS No.	2121512-14-7
Molecular Formula	C13H11BF2O3
Molecular Weight	264.04 g/mol
Synonyms	(2-(Benzyloxy)-4,5-difluorophenyl)boronic acid; 4,5-Difluoro-2-(phenylmethoxy)benzeneboronic acid; 2-(Benzyloxy)-4,5-difluorobenzeneboronic acid; B-[2-(Benzyloxy)-4,5-difluorophenyl]boronic acid; 2121512-14-7; Boronic acid, B-[2-(benzyloxy)-4,5-difluorophenyl]-; AKOS026710793
EINECS	Contact for details

Quality Control

Every batch of 2-Benzyloxy-4,5-Difluorophenylboronic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive coupling reactions. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as purity (by HPLC/NMR), identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.