Description

2-Fluoro-3-(Methylsulfanyl)Phenylboronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic ester, designed for advanced cross-coupling reactions. Its core value lies in enabling the precise and efficient synthesis of complex, sulfur- and fluorine-containing aromatic scaffolds, which are critical motifs in modern pharmaceutical and agrochemical discovery. This compound is essential for R&D chemists and process development scientists in the life sciences sector who require reliable, high-purity intermediates for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-couplings for synthesizing drug candidates containing fluorinated biaryl or heterobiaryl structures.
• Agrochemical Synthesis: Used to introduce the 2-fluoro-3-(methylthio)phenyl moiety into novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials and liquid crystals.
• Chemical Biology Probes: Facilitates the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) serving diverse client projects.

Basic Information

Product Name	2-Fluoro-3-(Methylsulfanyl)Phenylboronic Acid Pinacol Ester
CAS No.	2121512-11-4
Molecular Formula	C₁₃H₁₈BFO₂S
Molecular Weight	268.15 g/mol
Synonyms	2-Fluoro-3-(Methylthio)phenylboronic Acid Pinacol Ester; (2-Fluoro-3-(Methylsulfanyl)phenyl)boronic Acid Pinacol Ester; 2-Fluoro-3-(Methylmercapto)benzeneboronic Acid Pinacol Ester; 4,4,5,5-Tetramethyl-2-[2-fluoro-3-(methylthio)phenyl]-1,3,2-dioxaborolane; Pinacol 2-Fluoro-3-(Methylthio)benzeneboronate; B-[2-Fluoro-3-(Methylsulfanyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(Methylsulfanyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity suitable for sensitive coupling reactions. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.