Description

4-Fluoro-3-Hydroxy-5-Methylphenylboronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, particularly those requiring a sterically protected boronate ester moiety. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and material science industries for Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides with specific activity profiles.
• Material Science Research: Serves as a precursor for creating functionalized polymers and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The protected boronate ester group enables efficient, palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes and diagnostic agents for biochemical research.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts.

Basic Information

Product Name	4-Fluoro-3-Hydroxy-5-Methylphenylboronic Acid, Pinacol Ester
CAS No.	2121512-07-8
Molecular Formula	C13H18BFO3
Molecular Weight	252.09 g/mol
Synonyms	4-Fluoro-3-hydroxy-5-methylbenzeneboronic acid pinacol ester; 2-(4-Fluoro-3-hydroxy-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Methyl-3-fluoro-4-hydroxyphenylboronic acid pinacol ester; Pinacol (4-Fluoro-3-hydroxy-5-methylphenyl)boronate; Boronic acid, B-(4-fluoro-3-hydroxy-5-methylphenyl)-, 1,1-dimethylethyl ester (9CI); (4-Fluoro-3-hydroxy-5-methylphenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Hydroxy-5-Methylphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and traceability for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.