Description

2-Fluoro-5-(Methylthio)Phenylboronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its value lies in its stability as a pinacol-protected boronic ester, which offers improved handling and shelf-life compared to the free acid form, making it a reliable reagent for complex synthesis. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing advanced molecular scaffolds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and this boronic ester, enabling the synthesis of complex biaryl structures.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially those containing fluorinated and thioether motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or conductive polymers, where the fluorine and sulfur atoms can tune electronic properties.
• Ligand and Catalyst Development: Useful for constructing sophisticated ligand frameworks in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Probe Development: Facilitates the synthesis of molecular probes and tags for studying biological systems and drug-target interactions.

Basic Information

Product Name	2-Fluoro-5-(Methylthio)Phenylboronic Acid Pinacol Ester
CAS No.	2121512-06-7
Molecular Formula	C₁₃H₁₈BFO₂S
Molecular Weight	268.15 g/mol
Synonyms	2-Fluoro-5-(Methylthio)Benzeneboronic Acid Pinacol Ester; 5-(Methylthio)-2-Fluorophenylboronic Acid Pinacol Ester; (2-Fluoro-5-(Methylthio)Phenyl)boronic Acid Pinacol Ester; 2-Fluoro-5-Methylsulfanylbenzeneboronic Acid Pinacol Ester; 2-Fluoro-5-(Methylmercapto)phenylboronic Acid Pinacol Ester; Pinacol [2-Fluoro-5-(Methylthio)Phenyl]boronate; 2121512-06-7
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) and spectroscopic confirmation (NMR) are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.