Description

2,4-Dibromo-5-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex fluorinated and halogenated biaryl scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) containing fluorinated and brominated aromatic motifs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where specific halogen substitution patterns are required for bioactivity.
• Material Science: Serves as a precursor for creating functionalized organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology: Useful for incorporating fluorinated probes into molecules for imaging and diagnostic applications.
• Academic & Industrial R&D: A versatile reagent for methodological development and library synthesis in medicinal chemistry programs.

Basic Information

Product Name	2,4-Dibromo-5-Fluorophenylboronic Acid Pinacol Ester
CAS No.	2121512-02-3
Molecular Formula	C12H14BBr2FO2
Molecular Weight	379.86 g/mol
Synonyms	2,4-Dibromo-5-fluorophenylboronic acid pinacol ester; 5-Fluoro-2,4-dibromophenylboronic acid pinacol ester; (2,4-Dibromo-5-fluorophenyl)boronic acid pinacol ester; 2-(2,4-Dibromo-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(2,4-dibromo-5-fluorophenyl)-1,3,2-dioxaborolane; B-(2,4-Dibromo-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,4-Dibromo-5-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive analytical data including HPLC purity, NMR (1H, 13C, 19F, 11B), and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom purity grades can be discussed to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.