Description

2-Bromo-6-Fluoro-3-(Methylthio)Phenylboronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. This compound matters because it provides a protected boronic acid functionality, offering superior stability and handling characteristics for complex cross-coupling reactions. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel, fluorinated heterocyclic scaffolds and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those targeting CNS disorders and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging the unique properties of the bromo-fluoro-thioether motif.
• Material Science: Serves as a monomer or building block for creating functionalized polymers and organic electronic materials with specific optoelectronic properties.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis, where the steric and electronic profile of the aryl group is critical.
• Chemical Biology Probes: Utilized for synthesizing tagged molecules and activity-based probes for studying biological pathways and protein function.
• Library Synthesis for HTS: A valuable scaffold for generating diverse compound libraries used in high-throughput screening (HTS) campaigns to identify new bioactive molecules.

Basic Information

Item	Information
Product Name	2-Bromo-6-Fluoro-3-(Methylthio)Phenylboronic Acid Pinacol Ester
CAS No.	2121512-00-1
Molecular Formula	C₁₃H₁₇BBrFO₂S
Molecular Weight	346.05 g/mol
Synonyms	2-Bromo-6-fluoro-3-(methylthio)benzeneboronic acid pinacol ester; (2-Bromo-6-fluoro-3-(methylthio)phenyl)boronic acid pinacol ester; 2-Bromo-6-fluoro-3-methylsulfanylbenzeneboronic acid pinacol ester; B-[2-Bromo-6-fluoro-3-(methylthio)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 2-Bromo-6-fluoro-3-(methylthio)phenylboronate; CAS 2121512-00-1
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Fluoro-3-(Methylthio)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and oxidation. The material is hygroscopic and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.