Description

4-Acetyl-2,3-Difluorophenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its stability as a protected boronic acid ester, which facilitates handling and storage compared to its free acid form. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules via cross-coupling reactions.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of novel drug candidates, particularly those requiring difluorinated and acetyl-substituted aromatic systems.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the specific substitution pattern can influence biological activity.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or molecular sensors, where fluorination tunes electronic properties.
• Chemical Biology & Proteomics: Can be utilized as a synthetic handle for bioconjugation or in the development of enzyme inhibitors and molecular probes.

Basic Information

Product Name	4-Acetyl-2,3-Difluorophenylboronic Acid Pinacol Ester
CAS No.	2121511-81-5
Molecular Formula	C₁₄H₁₇BF₂O₃
Molecular Weight	282.10 g/mol
Synonyms	2,3-Difluoro-4-acetylphenylboronic acid pinacol ester; (4-Acetyl-2,3-difluorophenyl)boronic acid pinacol ester; 4-Acetyl-2,3-difluorobenzeneboronic acid pinacol ester; Pinacol (4-acetyl-2,3-difluorophenyl)boronate; 4-Acetyl-2,3-difluorophenyl-Bpin; B-(4-Acetyl-2,3-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2121511-81-5
EINECS	Contact for details

Quality Control

Our 4-Acetyl-2,3-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.