Description

4-Benzyloxy-2-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its stability as a protected boronic acid ester, facilitating efficient Suzuki-Miyaura cross-coupling reactions. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethoxy and benzyloxy aryl motifs.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds to create biaryl structures, a fundamental reaction in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and molecular recognition.
• Organic Electronic Materials: A potential monomer for constructing conjugated polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and target engagement.

Basic Information

Product Name	4-Benzyloxy-2-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester
CAS No.	2121511-68-8
Molecular Formula	C20H22BF3O4
Molecular Weight	394.20 g/mol
Synonyms	4-(Benzyloxy)-2-(trifluoromethoxy)benzeneboronic acid pinacol ester; [4-(Benzyloxy)-2-(trifluoromethoxy)phenyl]boronic acid pinacol ester; 2-(Trifluoromethoxy)-4-(phenylmethoxy)benzeneboronic acid pinacol ester; Pinacol [4-(benzyloxy)-2-(trifluoromethoxy)phenyl]boronate; 4-(Benzyloxy)-2-(trifluoromethoxy)phenylboronic acid, pinacol ester; Boronic acid, B-[4-(phenylmethoxy)-2-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-2-(Trifluoromethoxy)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to prevent moisture ingress. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.