Description

3-Fluoro-2-Formyl-5-Methylphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl and a boronic acid group on a fluorinated aromatic ring, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom and boronic acid group contribute to improved biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of novel organic electronic materials, sensors, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: An essential electrophilic partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures, a cornerstone of modern medicinal chemistry.
• Ligand and Catalyst Development: Utilized in the creation of novel bidentate ligands for asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and protein-protein interactions due to its reactive functional groups.

Basic Information

Product Name	3-Fluoro-2-Formyl-5-Methylphenylboronic Acid
CAS No.	2121511-45-1
Molecular Formula	C8H8BFO3
Molecular Weight	181.96 g/mol
Synonyms	(3-Fluoro-2-formyl-5-methylphenyl)boronic acid; 2-Formyl-3-fluoro-5-methylbenzeneboronic acid; 3-Fluoro-5-methyl-2-formylphenylboronic acid; Boronic acid, B-(3-fluoro-2-formyl-5-methylphenyl)-; 3-Fluoro-2-formyl-5-methylbenzeneboronic acid; CAS 2121511-45-1
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Formyl-5-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.