Description

2-Chloro-5-Fluoro-3-Methylphenylboronic Acid CAS NO 2121511-44-0 is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, crop protection, and electronic material development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing complex, substituted biphenyl or heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the chloro-fluoro-methyl substitution pattern can confer specific biological activity.
• Material Science Research: Serves as a monomer or building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a core structure in metal-organic frameworks (MOFs).
• Chemical Biology & Probe Synthesis: Utilized in the creation of molecular probes and tags for studying biological processes, leveraging the boronic acid group's affinity for diols.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Details
Product Name	2-Chloro-5-Fluoro-3-Methylphenylboronic Acid
CAS No.	2121511-44-0
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(2-Chloro-5-fluoro-3-methylphenyl)boronic acid; 2-Chloro-5-fluoro-3-methylbenzeneboronic acid; Boronic acid, B-(2-chloro-5-fluoro-3-methylphenyl)-; 2-Chloro-5-fluoro-m-tolylboronic acid; 3-Methyl-2-chloro-5-fluorophenylboronic acid; 2121511-44-0; B-(2-Chloro-5-fluoro-3-methylphenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-3-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.